KMID : 0352319990220010216
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Journal of KyungHee Oriental Medicine College 1999 Volume.22 No. 1 p.216 ~ p.236
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A Study on the Anticoagulative, Antiinflammatory, Analgesic and Antioxidative Effects of Kwuichulpajing-tang Aqua-acupuncture
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Song Eun-Hee
Lee Kyung-Sub Song Byoung-Key
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Abstract
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This study was projected to investigate the effects of Kwuichulpajing-tang aqua-acupuncture solution manufactured by water-alcohol method.
In vivo, to observe the anticoagulative, antiinflammatory and analgesic effects of Kwuichulpajing-tang aqua-acupuncture at Kwanwon(CV4), the experimental animals were divided into a normal, control and two experimental groups. Each of them had 6 animals. As the normal group was untreated, the control group was injected with normal saline(0.1§¢/100g) at Kwanwon(CV4) s.c., and then injected with induction medicine. One of the experimental groups (Sample I group) was injected with 25.0 §·/§¢ Kwuichulpajing-tang aqua-acupuncture solution(0.1§¢/100g) at Kwanwon (CV4) s.c., and then injected with induction medicine. The other experimental group(Sample¥±group) was injected with 50.0 §·/§¢ Kwuichulpajing-tang aqua-acupuncture solution (0.1§¢/100g) at Kwanwon(CV4) s.c., and then injected with induction medicine. The results of the experimental groups were compared with that of the control group.
In vitro, the effects of Kwuichulpajing-tang aqua-acupuncture solution on hyaluronidase activity, hydrolysis of casein by trypsin, heat-induced hemolysis and the antioxidative effect were observed.
The results were as follows :
1. The effects of Kwuichulpajing-tang aqua-acupuncture at Kwanwon on the
intravascular coagulation in rats induced by endotoxin(0.5§·/§¸) i.v. were that the blood platelet and white blood cell counts were significantly increased in both experimental groups. the blood fibrinogen content was significantly increased in Sample¥±group and the prothrombin, the activated partial thromboplastin and thrombin times were significantly shortened in both experimental groups.
2. The carrageenin-induced mice paw edema was significantly decreased in both
experimental groups.
3. The histamine-induced mice paw edema was significantly decreased in both
experimental groups.
4. The histamine-induced vascular permeability was significantly decreased in Sample¥±group.
5. The writhing syndrome induced by acetic acid was significantly decreased in Sample¥±group.
6. The response time of mice on 70¡É heat plate was significantly prolonged in Sample¥±group.
7. The hypnotic duration induced by pentobarbital-Na was significantly increased in both experimental groups.
8. Kwuichulpajing-tang aqua-acupuncture solution had antioxidative effect and inhibited hyaluronidase activity, trypsin activity on hydrolysis of casein and heat-induced hemolysis in vitro.
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KEYWORD
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